Cisplatin pten

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August undefined, 2024

WebFeb 7, 2014 · PTEN, a tumor suppressor gene, has been demonstrated to be able to reverse cisplatin-resistance in ovarian cancer cell line C13K. However, the downstream … WebJul 5, 2024 · Another in vivo study showed a synergistic effect of Cisplatin used in combination with the CK2-targeting compound CIGB-300, in nude mice xenografted with human cervical tumor cells, and an increased mice survival compared to single-agent treatment was observed [].The rationale of targeting CK2 in combination with Cisplatin …

BioStudies < The European Bioinformatics Institute < EMBL-EBI

WebNov 19, 2024 · Cisplatin is an anti-cancer chemotherapy drug which used to treat ovarian cancer in women who have already received surgery and/or radiation treatment. … WebSep 18, 2024 · NCBI Bookshelf iphone 11 pro max case

Cisplatin Uses, Side Effects & Warnings - Drugs.com

WebSep 8, 2024 · Cisplatin (cis-Diamminedichloroplatinum II) has been widely and effectively used in chemotherapy against tumors. Nephrotoxicity due to cisplatin is one of the most … WebMay 10, 2013 · PTEN protein levels were found to be decreased significantly in A2780 cells; however, there was no change in PTEN protein levels in A2780-CP, OVCAR-3 and SKOV3 cells with cisplatin treatment. The decrease in PTEN protein was accompanied with an increase in the levels of AKT phosphorylation (pAKT) in A2780 cells and a decrease of … WebConclusion: TGF-β induced TMEPAI contributes to the reduced response of TNBC treatment to doxorubicin and paclitaxel, but minimal on cisplatin and bicalutamide. Further study is needed to confirm our findings in other growth factor-induced cells, as well as in in vivo model. Keywords: TMEPAI, TGF-β, doxorubicin, paclitaxel. iphone 11 pro max case otter box mag

PTEN-Induced Putative Kinase 1 (PINK1)/Parkin-Mediated

Cisplatin and phenanthriplatin modulate long-noncoding RNA …

WebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), … WebCisplatin / pharmacology Cyclin-Dependent Kinase Inhibitor p27 / metabolism Drug Synergism Female Gene Expression Regulation, Neoplastic / drug effects Humans Intracellular Signaling Peptides and Proteins / antagonists & inhibitors Intracellular Signaling Peptides and Proteins / genetics* Intracellular Signaling Peptides and Proteins / … iphone 11 pro max case otter box mag safeWebSep 28, 2007 · We report that EF24, a synthetic compound 3,5-bis (2-flurobenzylidene)piperidin-4-one, greatly inhibits cisplatin-resistant (CR) human ovarian cancer cell proliferation. The inhibitory effect of EF24 on cell proliferation is associated with G (2)/M phase cell cycle arrest and increased G (2)/M checkpoint protein (pp53, p53, … iphone 11 pro max case for girls

"WebBackground: Platinum-based chemotherapy, cisplatin (DDP) specifically, is the main strategy for treating lung cancer (LC). However, currently, there is a lack of predictive drug-resistance markers, and there is increased interest in the development of a reliable and sensitive panels of markers for DDP chemotherapy-effectiveness prediction. MicroRNAs … " - Cisplatin pten

Cisplatin pten

BioStudies < The European Bioinformatics Institute < EMBL-EBI

WebPTEN is a tumor-suppressor gene deactivating PI3K downstream of EGFR signaling. We hypothesize that PTEN-deficient lung cancer cells suppressed DNA damage signaling and that the absence of PTEN can sensitize these cells to a concurrent treatment of a DNA-damaging agent (cisplatin) and a PARP inhibitor (olaparib).

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WebAug 27, 2024 · Plasmids PTEN-shRNA and PTEN-NC, which contain green fluorescent protein (GFP) and anti-puromycin genes, were extracted from glycerol bacteria and purified according to the manufacturer’s protocols. GC cells were cultured in DMEM/F-12 with 10% FBS in 6-well plates until they reached 70%–80% confluence. WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often …

WebFeb 1, 2013 · We hypothesize that PTEN -deficient lung cancer cells suppressed DNA damage signaling and that the absence of PTEN can sensitize these cells to a concurrent treatment of a DNA-damaging agent (cisplatin) and a PARP inhibitor (olaparib). WebApr 13, 2024 · HIGHLIGHTS who: Florentine S. B. Subtil et al. from the Department of Radiotherapy and Radiooncology, Philipps-University, Marburg, Germany have published the research: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic … Dual pi3k/mtor inhibitor nvp-bez235 leads to a synergistic enhancement of cisplatin and …

WebMay 17, 2024 · Cisplatin is a bifunctional platinum (II) complex with two chloride leaving ligands. The monofunctional platinum (II) complex, phenanthriplatin, has one chloride leaving ligand, and steric bulk... WebSep 24, 2024 · The main lipid substrate of PTEN is PIP 3 and indeed PTEN acts as a negative regulator of PI3K/AKT signaling. ... Wu, D. M. et al. The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance ...

WebMar 22, 2024 · Diaminodichloroplatinum (cisplatin, DDP) is one of the most effective and widely used DNA-damaging anticancer drugs used for the treatment of various human malignancies including NSCLC [ 4 ]. However, NSCLC patients who are initially sensitive to cisplatin often develop drug resistance, leading to chemotherapy failure [ 5 ].

WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … iphone 11 pro max charger wattWebApr 25, 2024 · In this study, we investigate the role of miRs and PTEN in renoprotective effect of curcumin against cisplatin-induced AKI in mice. It is aimed to reveal the mechanism of curcumin which protected the kidney and provided evidence on the therapeutic application of curcumin in alleviating AKI. Go to: Materials and methods Drugs iphone 11 pro max case reviewsWebPRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. Data files. Show entries ... neurons (SGNs) are auditory neurons that relay sound signals from the inner ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing … iphone 11 pro max case with initialsWebApr 13, 2024 · According to investigations, CAFs promote the survival of HPV-negative HNSCC after cisplatin treatment [7, 113], as well as HPV-positive and negative cells that receive cetuximab [114, 115] and ... iphone 11 pro max casingWebMay 10, 2013 · PTEN is found to be either inactivated or mutated in various human malignancies. In the present study, we have investigated the regulation of PTEN during cisplatin induced apoptosis in A2780, A270-CP (cisplatin resistant), OVCAR-3 and SKOV3 ovarian cancer cell lines. Methods: Cells were treated with 10μM of cisplatin for 24h. iphone 11 pro max chargingWebThis is the case of vesicular miR-21 that induced cisplatin resistance in oral squamous cell carcinoma by targeting phosphatase and tensin homolog (PTEN) and programmed cell death protein 4 (PDCD4), which are tumor suppressors involved in apoptosis, cell transformation, invasion, and tumor progression . iphone 11 pro max christmas caseWebJun 18, 2015 · Drug resistance is a major cause of treatment failure in ovarian cancer patients, and novel therapeutic strategies are urgently needed. Overexpression of phosphatase and tensin homolog (PTEN) has been shown to preserve the cisplatin-resistance of ovarian cancer cells, while cisplatin-induced keratin 10 (KRT10) … iphone 11 pro max commuter series case