Cisplatin treatment for oropharyngeal cancer

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August undefined, 2024

WebDec 15, 2024 · Various trials have examined induction cisplatin-based chemotherapy followed by reduced radiation doses or volumes. Induction chemotherapy can be used for risk stratification with the assumption that adjuvant RT can be reduced in good responders. WebNov 15, 2024 · Cisplatin-based chemoradiotherapy and cetuximab bioradiotherapy are both approved by the US Food and Drug Administration for treatment of head and neck cancer, with cisplatin being standard of care for advanced oropharyngeal squamous cell carcinoma in most countries.

ESMO Press Release Cetuximab vs cisplatin HPV

WebJan 7, 2024 · Cisplatin treatment was administered as a triweekly regimen, which differs from this study where weekly, low-dose treatment was used. There was a significantly increased risk of grade 3 increase in serum-creatinine (3.0 to 6.0 times the upper limit of normal serum-creatinine) in the saline group. WebApr 7, 2024 · Local recurrence is the most common pattern of failure in head and neck cancer. It can therefore be hypothesised that some of these patients would benefit from an intensified local treatment, such as radiation dose escalation of the primary tumour. This study compares treatment and toxicity outcomes from two different boost modalities in … slowing hair growth

Traditional chemotherapy superior to new alternative for …

WebFeb 21, 2024 · Although de-intensification strategies have been propelled to the forefront of clinical research in human papillomavirus (HPV) positive oropharyngeal cancer, three … WebMay 27, 2024 · The majority of newly diagnosed oropharyngeal squamous cell carcinoma (OPSCC) is associated with human papillomavirus (HPV) infection, portending very good … software mfa

Head and Neck Cancers Treatment Regimens - Cancer …

Dose escalation in oropharyngeal cancer: a comparison of …

WebApr 12, 2024 · The association of cisplatin pharmacokinetics and skeletal muscle mass in patients with head and neck cancer: the prospective PLATISMA study. Eur. J. Cancer 160, 92–99 (2024). •• Pivotal study investigating the mechanism of cisplatin toxicity in sarcopenia.Crossref, Medline, CAS, Google Scholar; 46. Lutz CT, Quinn LS. WebNov 10, 2024 · Patients were generally treated with concurrent high dose cisplatin (100 mg/m 2 given every three weeks), excluding patients aged ≥ 70, those with comorbidities or poor performance status or those who declined. Weekly cisplatin (40 mg/m 2) could be used at the discretion of the medical oncologist. software mg2570sWebJan 29, 2024 · A combination of reduced-dose radiotherapy using intensity-modulated radiotherapy (IMRT) combined with concurrent cisplatin met the threshold for disease … slowing in music abbr

"http://www.nrgoncology.org/Home/News/Post/treatment-de-intensification-for-early-stage-hpv-positive-oropharyngeal-cancer-nrg-hn005 " - Cisplatin treatment for oropharyngeal cancer

Cisplatin treatment for oropharyngeal cancer

The Current Treatment Paradigm of Early-Stage HPV-Related …

WebWe found no significant differences in survival or grade ≥ 3 side effects comparing simultaneous integrated boost and brachytherapy boost as alternative dose escalation modalities in the treatment of oropharyngeal cancer. Supplementary Information The online version contains supplementary material available at 10.1186/s13014-023-02256-x. WebMar 23, 2024 · The chemo drugs used most often for cancers of the oral cavity and oropharynx that can be given with or without radiation include: Cisplatin Carboplatin 5 …

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WebAug 13, 2024 · Oropharyngeal Cancer Intervention / Treatment Drug: Cisplatin Procedure: Radiotherapy Drug: Durvalumab Detailed Description The CompARE Trial examines alternative regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer in an adult patient population. WebOct 22, 2024 · This study shows that the best treatment choice for patients with HPV-positive throat cancer is cisplatin and radiotherapy. This combination gives ‘double’ the …

WebNov 9, 2024 · INTRODUCTION Human papillomavirus (HPV) infection, a common sexually transmitted disease, has been associated with the development of many cancers, including oropharyngeal squamous cell carcinoma (OPSCC) of the head and neck. (See "Virology of human papillomavirus infections and the link to cancer" .) While traditional, … WebOct 1, 2024 · Cetuximab represents a potential option for those ineligible for cisplatin or, until recently, an agent for de-escalation in low risk HPV+ oropharyngeal carcinoma (OPSCC). Our objective was to...

WebOct 1, 2013 · Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor … WebCisplatin chemoradiotherapy provided more QALYs and was less costly than cetuximab bioradiotherapy, remaining standard of care for nonsurgical treatment of HPV-positive …

WebAug 5, 2024 · This growing evidence supports cisplatin-based radiotherapy as the standard of care for patients with HPV/p16-positive cancer with low risk (e.g. non-smokers or < 10 pack-years smoking history) [ 9 ]. We also found the survival benefit with cisplatin therapy to be consistent among those who smoke and those with advanced age.

WebOct 22, 2024 · This study shows that the best treatment choice for patients with HPV-positive throat cancer is cisplatin and radiotherapy. This combination gives ‘double’ the benefit since it is more effective in terms of survival and does not worsen all grade toxicity compared to cetuximab with radiotherapy.” slowing inflationWebApr 11, 2024 · Eisenberger M, Hornedo J, Silva H, et al. Carboplatin (NSC-241-240): an active platinum analog for the treatment of squamous-cell carcinoma of the head and neck. J Clin Oncol 1986; 4:1506. Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008; 359:1116. slowing home salesWebTreatment for oropharyngeal cancer may include: Surgery Radiotherapy Chemotherapy Chemoradiation Immunotherapies You may have some treatments as part of a clinical trial. After oropharyngeal cancer treatment You have regular follow-up appointments after treatment with your specialist doctor. These may continue for several years. slowing in music abbreviationWebMay 20, 2024 · The current treatment landscape for oropharyngeal cancer At one time, traditional open surgery was a common treatment for oropharyngeal cancer, often … software mg3650WebOropharyngeal Cancer—Lessons Learnt from Recent Trials Hisham Mehanna Introduction Human papillomavirus (HPV)—mediated oropharyngeal cancer (OPC) has been ... it is widely acknowledged that treatment with cisplatin increases the number of acute serious toxicities by a factor of two, compared to radiotherapy alone [4]. It also demonstrates ... software mg2550sWebJun 6, 2024 · Results of our study show that, in the setting of low-risk oropharyngeal squamous cell carcinoma, the use of cetuximab bioradiotherapy instead of cisplatin-based chemoradiotherapy resulted in no overall benefit in terms of toxicity but showed significant detriment in tumour control. software mg5350WebJan 7, 2024 · Cisplatin treatment was administered as a triweekly regimen, which differs from this study where weekly, low-dose treatment was used. There was a significantly … slowing in music