WebZygotic demethylation at the 2- to 8-cell stage occurs in a passive manner. Zygotic expression of DNMT1 is low, and maternal DNMT1 (inherited from the oocyte) is … Demethylating agents are chemical substances that can inhibit methylation, resulting in the expression of the previously hypermethylated silenced genes (see Methylation#Cancer for more detail). Cytidine analogs such as 5-azacytidine (azacitidine) and 5-azadeoxycytidine (decitabine) are the most commonly used demethylating agents. They work by inhibiting DNA methyltransferases. Both compounds have been approved in the treatment of myelodysplastic syndrome (MDS) by F…
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Demethylation - Wikipedia
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