WebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance of individual subunits in maintaining cellular homeostasis is unknown. WebThe light intermediate chains associate in the dynein complex only as homoligomers. b Each light chain family has at least 2 members. ... Dynein is part of a complex including …

A transient helix in the disordered region of dynein light …

WebJun 1, 2002 · Light intermediate chain of the cytoplasmic dynein complex 2, a multisubunit complex composed at least of eleven different proteins. The cytoplasmic … WebThese complex and large molecules consist of dynein heavy chains (DHC), dynein light chains (DLC), and dynein intermediate chains (DIC). While DHC binds to MTs, DLCs are involved in binding to cargo EEs. The activity of dynein is regulated by a number of factors including dynactin, i.e., a multi-subunit protein complex that plays several roles ... cisco asa dynamic access policy example

Roles of the multivalent dynein adaptors BicD2 and RILP in neurons

WebDec 23, 2016 · Dynein is a large, non-covalent cytoplasmic complex of protein subunits including heavy chains, intermediate chains, light … WebKASH5 interacts with a dynein light intermediate chain (DYNC1LI1 or DYNC1LI2) via a conserved helix in the LIC C-terminal, and this region is also needed for dynein's recruitment to other cellular membranes. KASH5's N-terminal EF-hands are essential as the interaction with dynein is disrupted by mutation of key calcium-binding residues ... WebOct 1, 2014 · The LIC domain structure has interesting parallels with the dynein intermediate chain, which has a well-ordered WD repeat domain that interacts with the heavy chain and a less conserved disordered … cisco asa dynamic crypto map ikev2