Gw9508 cayman chemical
WebGW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC 50 values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC 50 = 6.14).
Gw9508 cayman chemical
Did you know?
WebCayman Chemical sso Sso, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 80/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more WebJun 5, 2024 · From the point view of chemical structure, GW9508 involves a phenylpropanoic acid in the molecule, which is vulnerable to glucuronidation to form acyl glucuronide. ... GW9508 was stable in rat plasma at −80 °C for 30 days, 25 °C for 12 h, 10 °C for 8 h in auto-sampler, and after three freeze (−80 °C)-thaw (25 °C) cycles. ...
WebNov 23, 2024 · Product name : GW9508 Product Number : G9797 Brand : Sigma CAS-No. : 885101-89-3 1.2 Relevant identified uses of the substance or mixture and uses advised against ... To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. SECTION 12: Ecological information 12.1 … WebGW9508 is shown to be at least 100-fold selective against 220 other GPCRs, 60 kinases, 63 proteases, seven integrins and 20 nuclear receptors including PPARα, δ and γ (pEC50 4.0, 4 and 4.9, respectively). ... Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Calculate. Total Molecular Weight: g ...
WebGW9508 is a free fatty acid receptor agonist able t o protect from ovariectomy-induced bone loss in vivo thought inhibition of osteoclast differentiation i n a G-coupled Protein Receptor 40 (GPR40)-dependent way. In this study, we questioned whether higher doses of GW9508 may also in fluence resorbing cell viability specifically. WebMar 19, 2015 · GW9508 or human eotaxin-1 (CCL11; 10 nM, R&D Systems, Minneapolis, MN) was placed in the lower chambers. To study the effect of GW9508 on eotaxin …
WebNov 15, 2013 · GW9508 is a free fatty acid receptor agonist able to protect from ovariectomy-induced bone loss in vivo thought inhibition of osteoclast differentiation in a G-coupled Protein Receptor 40 ... from 5-bromo-2-furaldehyde and 3-carboxybenzeneboronic acid in 3 and 4 steps with 29–49% and 24–32% overall chemical yield, respectively.
WebDec 8, 2024 · Mechanistically, we showed that GW9508 promoted ox-LDL-induced transcriptional factor NF-E2-related factor 2 (NRF2) (increase by 47.3%) translocation into the nucleus. The effect of GW9508 is dependent on its receptor GPR120, the blockage of which by its specific antagonist, AH7614, abolished the antisenescence effect of GW9508. eashionpremier池袋東武店WebCayman Chemical gw9508 Gw9508, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more eashing surrey mapWebNov 17, 2016 · GW9508 (Cayman Chemical) was administered to adult (5 months old) male C57BL6 mice through the diet at a dose calculated to yield an intake of 50 μg g −1 body weight per day GW9508 intake 55 ... eashing ward royal surreyWebGW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC 50 values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors … eashion バイトWebCayman Chemical Company supplies scientists worldwide with the resources necessary for advancing human and animal health. We manufacture high quality biochemicals, assay … ctv anchors maleWeb欢迎您访问武汉艾美捷科技有限公司官方网站！ eashingtonian best spas 2018WebNov 15, 2013 · As described above, cells were first serum starved and then incubated for 24 h in the presence of vehicule (DMSO) or 1–100 µM of GW9508 (Cayman … ctv anchor women