WebAug 1, 2015 · OptKnock's outer problem selects reactions to delete while the inner problem uses FBA to maximize cellular growth given those deletions and returns the corresponding chemical production rate to the outer problem. OptKnock identifies those deletions with the highest chemical production at the maximum growth rate. WebReacKnock: identifying reaction deletion strategies for microbial strain optimization based on genome-scale metabolic network. PLoS ONE . 2013, 8 (12): e72150. 2. Jing Meng#, Xu Zixiang #, et.al.. Analysis of enhanced current-generating mechanism of Geobacter sulfurreducens strain via model-driven metabolism simulation.
First ten alternative solutions provided by ReacKnock for …
WebApr 25, 2024 · Three different methodologies are presented to solve the bi-level problem in metabolic engineering. Based on original research and methodologies adopted by people well versed in the area. Methodologies looping strategy milp reformulation (based on papers such as Optknock and Reacknock) callbacks WebJan 1, 2024 · ReacKnock can screen up to 20 gene knockout targets [100]. OptStrain can search knockout targets from a reaction library, which contains a series of enzyme … chinese buffet avon indiana
ReacKnock: identifying reaction deletion strategies for microbial ...
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